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What Are Collagen Stimulating Fillers?

Radiesse® and Sculptra® are widely used FDA-approved collagen stimulating fillers. They activate the production of your own collagen and elastin. These injectables restore facial volume in areas like the cheeks, temples, and jawline for a more youthful look.

These products reduce the appearance of moderate and harsh wrinkles like the nasolabial folds, parentheses lines, chin wrinkles, and marionette lines. You may or may not notice an immediate result, however, the end result is natural and long lasting.


Sculptra®’s formula is designed to focus entirely on enhancing the body’s natural production of collagen and elastin proteins. Boosting production of these proteins results in firmer, thicker, and younger-looking skin.

Sculptra® utilizes the body’s inflammatory response to stimulate collagen and elastin production. Once injected into the skin, Sculptra® triggers the immune system to create new fibroblasts. Fibroblasts are cells that create collagen and elastin protein in the skin.

This collagen stimulator is composed of poly-L-lactic acid (PLLA). Poly-L-lactic acid is a synthetic material similar to implantable medical devices that dissolve, like medical sutures.

It is naturally and safely absorbed by the body over time.

Unlike other fillers, which produce immediate results, Sculptra® is for patients who prefer natural-looking and longer-lasting results that develop over time.

Sculptra® may begin to show visible results in six weeks or more, depending on your body’s reaction to the dermal filler. Results from a Sculptra® treatment can last for more than two years.

Collagen Stimulating Fillers Before & After

Wrinkled neck before collagen stimulating fillers in Atlanta
Tighter neck after collagen stimulating fillers in Atlanta


Most minimally invasive treatments today target the immune system or the body’s natural healing process to stimulate collagen production. Radiesse® works differently, in that it is a non-inflammatory biostimulator.

Radiesse® is formulated with tiny calcium hydroxylapatite (CaHA) microspheres suspended in an aqueous gel solution. CaHA activates fibroblasts to boost collagen and elastin production.

Radiesse® microspheres are embedded in the skin tissues, creating a scaffolding effect that immediately enhances structure and increases volume. These microspheres also promote the growth of new collagen and elastin for lasting results even after the microspheres naturally dissipate.

Radiesse® is ideal for people who want immediate anti-aging results. Its benefits can last for 12 to 18 months.

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What Areas Are Treated With Collagen Stimulating Fillers?

When used in their original forms, collagen stimulating fillers provide volume and structure and are most often used in the face. However, in diluted form, they provide long term tissue remodeling.

This diluted formulation allows for superficial injection and is best for dermal rejuvenation of larger areas such as neck, chest, arms, knees, and buttocks.

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Patient Testimonials

I get lip fillers and now cheek fillers. My visit today was great and as always, Natalie was fabulous! I had some questions about different types of fillers to potentially try this time, and she explained everything fully and gave her suggestions. She was right on the money and I love my fillers. Everyone there is so nice and friendly. Highly recommend them!

- Carla

Love the staff and my fillers were IMMEDIATE results! I love it!!!!

- Blanca
Woman getting collagen stimulating fillers in Atlanta
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Will the Procedure Be Painful?

No, the procedure is not painful. Depending on the area to be treated, usually one to three sites are numbed with local anesthetic. A cannula is then used to place the product. This is generally well tolerated. Another option is to place topical anesthetic on your skin before gently placing small aliquots of product spread evenly throughout the area of concern.

What is the Aftercare of the Treatment?

You may experience mild swelling and bruising at the site of injection, but no aftercare is generally required. In some instances, you may be asked to massage the treated area several times a day. We ask that you wait until the next day to return to exercise.

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How Soon Will I See

Results vary, and you may see some initial improvement. Final results will be achieved in 12 weeks. Your provider will want to see you 12 weeks after your first treatment.

How Many Treatments Will I Need?

The number of treatments varies according to the amount of skin laxity. One treatment may be enough or you may need 2-3 treatments to achieve optimal results.

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Select a location, Choose a provider, then Book your procedure. It’s that easy! Marietta Plastic surgery wants to introduce our new online appointment calendar. It’s easier now more than ever to choose your favorite provider and get the services you need at the time you want. Marietta Plastic Surgery proudly serves Marietta, Woodstock, and Atlanta, Georgia and the entire southeastern United States.

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